@AFC_cristal
| Intitulé du poste : | Postdoctoral position |
| Ville : | Montpellier |
| Laboratoire/Institut : | Center for Structural Biology (CBS) Team “Nuclear receptors as integrators of endogenous and environmental signals” (https://www.cbs.cnrs.fr/index.php/en/home-equipea5) |
| Projet: | A number of compounds present in the environment act as endocrine disruptors and cause adverse effects in humans and wild-life by interfering with the normal signaling of various cellular targets. Mounting data suggest a link between the increasing exposure to these chemicals and the development of diseases including reproduction defects, hormone-related cancers, or metabolic disorders. Our team is using a battery of structural, biophysical and cell-based approaches to provide a rational framework for better understanding and combating the impact of environmental pollutants on human health. The position requires the applicant to work on structural and biochemical characterization of various receptors including the peroxisome proliferator activated receptor g (PPARg ), the pregnane X receptor (PXR) and the aryl hydrocarbon receptor (AHR). Recent publications of the team in the field: - Kwong HS, et al. Structural insights into the activation of human Aryl Hydrocarbon Receptor by the environmental contaminant benzo[a]pyrene and structurally related compounds. J Mol Biol. 2023 Dec 20:168411. - Gruszczyk J, et al. Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex. Nat Commun. 2022 Nov 16;13(1):7010. - Delfosse V, et al. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2020551118. |
| Qualifications: | Applicants must hold a PhD in biological sciences (preferably in biochemistry or structural biology), and should have a strong background in protein expression and purification, cryogenic electron microscopy and/or X-ray crystallography. |
| Durée du contrat: | 2-year postdoctoral research fellow funded by the French National Research Agency. |
| Début du contrat: | 1st of September 2024 |
Procédure pour candidater: |
The application, including CV, motivation letter and 2 reference letters, should be sent to |
| Contact: |
