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Intitulé du poste : Cryo-EM specialist position
Ville : Strasbourg
Laboratoire/Institut : CBI / IGBMC

The CBI https://www.igbmc.fr/en/plateformes-et-services/infrastructures/centre-for-integrative-biology provides a leading-edge scientific and technological environment in integrated structural biology to address the structure and function of biological systems, notably on gene expression, from the atomic, molecular to the tissue scales. The platform for Integrated Structural Biology at the CBI https://biostructure.igbmc.fr/ provides support for protein sample production (bacterial, eukaryotic, mammalian cell expression etc.), characterization and structural analysis using various approaches. The CBI hosts the French and European Infrastructures for Integrated Structural Biology, FRISBI https://frisbi.eu, Instruct-ERIC http://instruct-eric.com and iNext-Discovery https://inext-discovery.eu.

The advanced cryo-EM facility comprises cutting-edge instrumentation such as two Titan Krios cryo electron microscopes and a Glacios cryo electron microscopes for cryo-EM and tomography, cryo Focused Ion Beam Scanning Electron Microscope (cryo-FIB/SEM) including for cryo FIB milling / lamella production, and super-resolution imaging (dSTORM).

The Titan Krios 1 microscope is equipped with K3 & Falcon 3 cameras and GIF energy filter, Volta phase plate (VPP) and Cs corrector,

the Titan Krios 2 microscope has a Falcon 4i camera, Selectris X energy filter, Volta phase plate (VPP),

the Glacios microscope has a K2 camera and a Ceta-D camera for micro electron diffraction (μED).

In addition, the EM facility has a suite of associated equipments for sample preparation (grid freezing with Vitrobot and new Chameleon high-speed freezing device, HPF etc.) and dedicated computing resources for image analysis, processing and 3D reconstruction by single particle cryo-EM (including on-the-fly data processing), cryo electron tomography (cryo-ET) and fluorescence microscopy, and a dedicated opto-meca micromechanics workshop for developing and prototyping new instruments. 

Description du poste :

An experienced cryo-EM scientist to participate in running the cutting-edge EM facilities at the Centre for Integrative Biology (CBI) at IGBMC, Illkirch/Strasbourg, France.

Formation requise et compétences clés Desired level of education : PhD
Experience required : 1 to 4 years

Durée du contrat : CDD 1 an
Date de prise de fonction : 1er février 2023
Date Limite Candidature 31 janvier 2023
 et lien pour la candidature

Interested candidates should apply at https://emploi.cnrs.fr/Offres/CDD/UMR7104-BETMOI-004/Default.aspx?lang=EN  and email a brief cover letter stating your interest, a CV with list of publications and names & contact information of three referees to Bruno Klaholz.

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