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Intitulé du poste : Post-doctoral position in RNA modification enzymes
Ville : Palaiseau
Laboratoire/Institut : 'Laboratory of Structural Biology of the Cell' at Ecole Polytechnique (CNRS, Institut Polytechnique de Paris, Palaiseau, France).
The lab is located 40 minutes by train from Paris city centre.
The lab is interested in understanding how epitranscritomic marks are deposited on RNAs and influence RNA translation and decay as well as cell proliferation and organ development.

Description du poste :

Come and join us to contribute to the characterization of the molecular and cellular functions of human RNA modification enzymes. You will work in close collaboration with teams located in Paris, Strasbourg (France), Belgium and Germany to investigate the role of some of these enzymes in cancer cell proliferation, in human diseases or in animal brain development.

Activities  You will have access to and/or will be able to learn the various experimental
approaches implemented in the lab : biochemistry (protein or RNA expression and purification, enzymology, pull-down, …), cell biology (CRISPR-Cas9 gene deletion, coimmunoprecipitation, purification of RNAs from human cell lines, …) and structural biology (X-ray crystallography) as well as to local state-of-the-art core facilities (live-cell imaging, LC/MS for nucleosides analyses…).

Formation requise et compétences clés The applicants should hold a PhD and have some expertise in molecular biology, biochemistry and cell biology. Interest in RNA translation as well as knowledge in RNA purification, confocal microscopy, luciferase-based assays, ribosome profiling or RNAseq will be very much appreciated. Working knowledge of the English language (scientific, oral and written) is necessary, but knowledge of French is not required as the team regularly hosts people from different countries. Enthusiasm, motivation and willingness to contribute to a dynamic and enjoyable working environment are very important qualities. The candidate should show autonomy, but a successful integration into the team projects is essential. The position is open immediately but the starting date is flexible depending on your availability.

Durée du contrat : 2-year

Date de prise de fonction : The position is open immediately but the starting date is flexible depending on your availability. 
Date Limite Candidature
 et lien pour la candidature

Applications (including a detailed CV, summary of your current project and relevant skills and a contact information of two/three references) or information requests should be sent to Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser.
Website: https://portail.polytechnique.edu/bioc/fr/presentation
Twitter : @GrailleLab

Personne à contacter :
Marc Graille