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Intitulé du poste : Post-doctoral position in Structural Biology

Ville : Université Paris-Saclay - INRAE
Laboratoire/Institut : ChemSyBio team (Université Paris-Saclay, INRAE, Micalis) headed by Dr Olivier Berteau & Dr Alhosna Benjdia.
Our research institute provides a vibrant and international environment for researchers interested in interdisciplinary research with access to state-of the art analytical and synchrotron radiation facilities.

Description du poste :

The project involves structure determination of novel metalloenzymes by X-ray crystallography in order to understand enzyme mechanism and reactivity. These enzymes generally combine multiple metallic centers to catalyze unprecedented reactions. Recently, we have uncovered unanticipated active-site rearrangements that challenge our current understanding of these metalloenzymes (Fyfe et al., Nature 2022). We aim at using state-of the art structural and spectroscopic techniques to unravel the unique catalysis of these novel enzymes.

Activities  
Formation requise et compétences clés We are seeking for a highly motivated post-doctoral fellow with a proven experience in X-ray crystallography. The candidate should have a PhD in structural biology with a good knowledge of protein expression/purification, crystallization and crystallography software.  A knowledge of Cryo-EM would be an asset for the project. The salary will be commensurate with experience.
Durée du contrat : The position is offered for one-year, renewable up to 3 years.
Date de prise de fonction :  
Date Limite Candidature
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