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Intitulé du poste : PhD in Structural Biology
Ville : Toulouse
Laboratoire/Institut : Institut de Pharmacologie et de Biologie Structurale
Description du poste : This PhD project relies on the collaboration of the groups " Ecologie et évolution des interactions " (C. Grunau, Université de Perpignan) and "structural biophysics (Lionel Mourey, IPBS, CNRS UPS) in Toulouse.
The selection pressure exerted on host-pathogen interactions favored the emergence a diverse array of toxins with defined cellular specificity. Recently, an ensemble of aerolysin related b-barrel pore forming toxins has been identified in the snail Biomphalaria glabrata, an intermediate host of the schitosomiasis vector (1). These 23 proteins, named biomphalysins, are built of two structural domains. The lytic domain, which is related to aerolysin, is responsible for pore formation in the target cell membrane, resulting from oligomerization. The smallest N-terminal domain is still of unknown function. In aerolysin, this N-terminal domain corresponds to a carbohydrate binding motif. Biomphalysins display hemolytic properties and are able to specifically recognize a large panel of pathogens, such as Gram positive and negative bacteria, yeast and metazoan parasites.
Our goal is to decipher the structural determinants of the cellular recognition properties of biomphalysins, which might reside in the N-terminal domains of the toxins.

1 Galinier et al. 2013. PLoS Pathog. 9: e100321
Durée du contrat : 3 ans
Date de prise de fonction : 1er octobre 2020
Personne à contacter : Laurent Maveyraud
Téléphone :  05 61 17 54 35
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